Price FDA-approved Zepbound first. LillyDirect charges $299 to $449 a month, and covered insurance can bring it to $25.

| Way to pay | What you pay | Good to know | Checked |
|---|---|---|---|
| Way to pay Telehealth, month to month Injection | What you pay $129–$359 per month | Good to know Median $207 across 8 providers that name tirzepatide next to a month-to-month price. One provider’s fall sale is $89. | Checked Sep 23, 2026 our provider data |
| Way to pay Telehealth, first month Injection | What you pay $99–$259 first month | Good to know Median $149 across 9 providers. Several raise the price in month two, for example $99 then $179 at System Labs. | Checked Sep 23, 2026 our provider data |
| Way to pay Telehealth, prepaid plans Injection | What you pay $125–$259 per month | Good to know Median $179 a month on each provider’s longest plan, often paid upfront, such as $1,500 a year at Trimi. | Checked Sep 23, 2026 our provider data |
| Way to pay A year, month to month (median) Injection | What you pay $2,484 per year | Good to know 12 months at the $207 median. | Checked Sep 26, 2026 our cost analysis |
| Way to pay Zepbound (FDA-approved), LillyDirect self-pay VialKwikPen | What you pay $299–$449 per month | Good to know 2.5 mg $299, 5 mg $399, 7.5 to 15 mg $449 if you refill within 45 days. Zepbound prices and providers. | Checked Sep 25, 2026 lilly.com |
| Way to pay Medicare Part D: GLP-1 Bridge KwikPen | What you pay Up to $50 per month | Good to know Covers the FDA-approved Zepbound KwikPen for eligible Part D enrollees through December 31, 2027. Compounded drugs aren’t part of it. | Checked Sep 26, 2026 medicare.gov |
Compare the month-to-month price, not the first-month offer. And price FDA-approved Zepbound before you commit: Lilly sells it for $299 to $449 a month on LillyDirect, and covered insurance can bring it to $25.
We track 23 telehealth providers that offer compounded tirzepatide. These 11 publish a tirzepatide price or are ones we’ve reviewed, sorted by the lowest monthly price each one lists. Plan length matters: some of the lowest prices need a year paid upfront. See all providers side by side.
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Price FDA-approved Zepbound first. LillyDirect charges $299 to $449 a month, and covered insurance can bring it to $25.
Compare month-to-month prices, not first-month offers. Some providers raise the price by 60% to 80% in month two.
On Medicare Part D? The GLP-1 Bridge covers the Zepbound KwikPen for up to $50 a month. Compounded drugs aren’t included.
Check who makes it. Ask for the compounding pharmacy’s name and license, and skip anyone who sells it without a prescription.
Prepay only if you’re sure. The lowest per-month prices often need a year paid upfront, and refunds are limited.
Be wary of “generic Zepbound” or “generic Mounjaro” claims. There is no generic tirzepatide, and the FDA has warned telehealth companies against that wording.
Compounded tirzepatide is tirzepatide mixed by a compounding pharmacy instead of made by Eli Lilly. It’s usually a weekly injection drawn from a multi-dose vial, and telehealth companies sell it with a prescription from their own clinicians.
Compounded drugs are not FDA-approved. During the tirzepatide shortage, pharmacies could make copies of Zepbound and Mounjaro. Since the FDA declared the shortage over in December 2024, copies are allowed only in limited cases, and the FDA has sent warning letters to dozens of telehealth companies over how they market them. On April 30, 2026, it also proposed excluding tirzepatide from the list of drugs outsourcing facilities can compound. A final decision is pending.
In August 2026 the FDA wrote to state medical boards about labeling and dosing risks with compounded GLP-1 vials. If you use one, confirm your dose in milligrams and units with the pharmacy. Our FDA-approved vs. compounded GLP-1s guide explains the differences.

At the providers we track, month-to-month plans cost $129 to $359 a month, with a median of $207. Prepaid plans bring the median to $179 a month, and first-month offers have a median of $149. One provider runs an $89 fall sale. We checked these prices on September 22 and 23, 2026.
Usually, yes. The median month-to-month price, $207, is less than half of Zepbound’s $449 self-pay price at 7.5 mg and up. But Zepbound can cost as little as $25 with covered insurance, or up to $50 for the KwikPen through the Medicare GLP-1 Bridge, and compounded drugs don’t qualify for either.
No. The FDA doesn’t review compounded drugs for safety, effectiveness or quality before they’re sold. As of May 31, 2026, it had received more than 730 adverse-event reports for compounded tirzepatide.
Not outright. Since the shortage ended in December 2024, pharmacies can make copies of FDA-approved tirzepatide only in limited cases, and a federal appeals court upheld the FDA’s decision on August 27, 2026. The FDA has also proposed keeping tirzepatide off the list outsourcing facilities can compound from. What’s changing for compounded GLP-1s.
No. Compounded versions aren’t tested or approved the way Zepbound is, and doses come from multi-dose vials that are easy to mismeasure. The FDA has told telehealth companies not to call compounded drugs “generic” or “the same as” a brand-name drug.
Many providers advertise a lower first month. In our data, System Labs charges $99 and then $179, and Found (cash, 1-month plan) charges $219 and then $359. Check the month-two price before you sign up.
Few providers bill insurance for it, and Lilly’s savings card and the Medicare Bridge don’t apply. Some providers accept HSA or FSA cards, including Eden, Trimi and SkinnyRx, per their sites.
It can carry more risk than FDA-approved tirzepatide, because the FDA doesn’t check its quality before it’s sold, and the FDA has flagged dosing risks with multi-dose vials. Work with a licensed clinician, use a state-licensed pharmacy, and confirm your dose in milligrams and units.
No. It’s a prescription drug. Legitimate providers require a medical intake and a prescription from a licensed clinician, so skip any site that sells it without one.
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We pulled month-to-month, first-month and prepaid prices from each provider’s own pricing pages on September 22 and 23, 2026, counting only prices that name tirzepatide. We read LillyDirect, Medicare.gov and the FDA’s compounding pages on September 25 and 26, 2026. We don’t buy the drug or sign up for plans. Every card shows when we checked it, and we recheck prices every month. If a price has changed, tell us.
Every provider on this page is an affiliate partner, and we earn a commission when you sign up through our links. Commissions never change the order or what we write. How we make money and our editorial policy explain the rules we follow. We drafted this page with AI assistance and checked every number against its source.


